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本文对1987年5月~1990年10月住院的102例痰菌阳性肺结核病人,在化疗中加服护肝药,以期预防肝损害的发生。本研究按入院先后随机分成两组。观察时间3~6月,化疗前肝功正常,疗程中每月验肝功1次。肝功异常者全部完成6个月全程观察。一、单纯化疗组 54例。男42例,女12例。18~62岁,平均36.7岁。化疗方案3SHRZ/6HRE或3SHR/6HDEZ。少数病例加用VC和VBco。二、护肝化疗组 48例。男42例,女6例。24~53岁,平均34.9岁。化疗方案及其它用药同单纯化疗组。另加服齐墩果酸片80mg,3/日,联苯双酯滴丸15mg,3/日)。
This article from May 1987 to October 1990 hospitalized 102 cases of sputum positive pulmonary tuberculosis patients, plus chemotherapy in the protection of liver medicine, in order to prevent the occurrence of liver damage. The study was randomly divided into two groups according to hospital admission. Observation of time from 3 to 6 months, normal liver function before chemotherapy, treatment of liver function test once a month. Hepatic abnormalities were all completed 6 months full observation. First, simple chemotherapy group of 54 cases. There were 42 males and 12 females. 18 ~ 62 years old, average 36.7 years old. Chemotherapy regimen 3SHRZ / 6HRE or 3SHR / 6HDEZ. A small number of cases plus VC and VBco. Second, Hugan chemotherapy group of 48 cases. 42 males and 6 females. 24 ~ 53 years old, average 34.9 years old. Chemotherapy and other drugs with chemotherapy alone group. Plus additional oleanolic acid tablets 80mg, 3 / day, diphenyl ester pills 15mg, 3 / day).