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美国食物与药物管理局(FDA)建议孕妇应避免喝含咖啡因的饮料,每天不超过5杯茶或咖啡。许多研究发现大量咖啡因(≥100mg/kg)非肠胃道给药对小鼠是致畸的,若按50或70mg/kg口服则轻度畸形或可疑增多。主要缺陷发生在趾、肢、皮下出血及腭裂。大鼠以≥75mg/kg口服给药后发现趾畸形。本实验主要研究口服咖啡因对CD1小鼠是否致畸以及咖啡因血浓度与畸形后代产生的关系。实验方法:(1)妊娠第5～18天经饮水给咖啡因(1.6g/l及0.8g/l),第18天颈椎脱
The United States Food and Drug Administration (FDA) recommends that pregnant women avoid drinking caffeinated beverages, no more than 5 cups of tea or coffee per day. Many studies have found that parenteral administration of large amounts of caffeine (> 100 mg / kg) is teratogenic to mice and mildly or suspiciously increased if given orally at 50 or 70 mg / kg. The main defects occurred in toes, limbs, subcutaneous hemorrhage and cleft palate. Toe deformities were found after oral administration of ≧ 75 mg / kg in rats. The main purpose of this study was to investigate whether teratogenic effects of oral caffeine on CD1 mice and the relationship between caffeine concentration and deformity of offspring. Experimental methods: (1) on the 5th to 18th days of gestation, drinking caffeine (1.6g / l and 0.8g / l)