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答:利血平的降压作用和肾上腺素能神经末梢的递质去甲肾上腺素(NA)的耗褐有密切关系。其机理一般认为有:(1)抑制囊泡膜上的Mg~(++)-ATP酶的主动摄取机制,使NA不能再回收而留在神经末梢中被单胺氧化酶(MAO)所破坏;(2)阻止多巴胺进入囊泡内,使NA合成减少;(3)损害囊泡膜,使囊泡内的NA弥散出来,继而又被MAO和儿茶酚氧位甲基转移酶所分解。由于
A: The antihypertensive effect of reserpine is closely related to the browning of the norepinephrine (NA), an adrenergic nerve endings. The mechanism is generally believed to be: (1) inhibition of the active uptake of Mg ~ (++) - ATPase on the vesicle membrane so that NA can not be recovered and remains damaged by monoamine oxidase (MAO) in nerve endings; ) Prevented dopamine from entering the vesicles and reduced NA synthesis; (3) damaged the vesicular membrane and caused the NA in the vesicles to diffuse out, which was subsequently decomposed by MAO and catechol oxygen methyltransferase. due to