论文部分内容阅读
研究发现,腺苷是支气管哮喘的重要介质之一。作者用尘螨致敏家兔复制人类哮喘模型,认为该模型非常适合反义DNA治疗,因为针对腺苷A_1受体的硫代反义寡核苷酸(A_1AS)能特异降低A_1受体mRNA的模板活性,抑制其基因的表达,同时雾化吸入A_1AS易进入支气管壁,并且该模型与人类哮喘的病理很相似,人和家兔腺苷A_1受体mRNA的起始密码相同。 哮喘家兔分两组,每组4只,分别吸入A_1AS和
The study found that adenosine is one of the important mediators of bronchial asthma. The authors used a dust mite-sensitized rabbit model to replicate human asthma and considered the model well suited for antisense DNA therapy because the thio-antisense oligonucleotide (A_1AS) directed against adenosine A 1 receptor specifically lowers A 1 receptor mRNA Template activity, inhibit the gene expression, inhalation of A_1AS inhalation easy access to the bronchial wall, and the model and human asthma pathology is very similar, human and rabbit adenosine A_1 receptor mRNA start codon the same. Asthma rabbits were divided into two groups, each group 4, inhaled A_1AS and