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目的:探讨中性粒细胞弹性蛋白酶(NE)在急性哮喘儿童中的应用价值。方法:选取我院80例哮喘儿童,其中急性发作45例(急性组)和非急性发作组35例(非急性组),另选取同期35例健康体检儿童作为对照组。用ELISA法检测各组外周血的NE和白细胞介素-8(IL-8)水平,并探讨二者的相关性。结果:哮喘组的NE和IL-8水平高于对照组,其中急性发作组高于非急性发作组(P<0.05);NE和IL-8水平呈正相关(r=0.48,P<0.01)。结论:NE水平可作为哮喘急性发作的诊断指标。
Objective: To investigate the value of neutrophil elastase (NE) in children with acute asthma. Methods: Eighty asthmatic children in our hospital were selected, including 45 cases of acute attack (acute group) and 35 cases of non-acute attack group (non-acute group). Another 35 healthy children were selected as control group. The levels of NE and interleukin-8 (IL-8) in peripheral blood of each group were detected by ELISA, and their correlation was also discussed. Results: The levels of NE and IL-8 in asthma group were higher than those in control group. The levels of NE and IL-8 in acute exacerbation group were higher than those in non-acute exacerbation group (r = 0.48, P <0.01). Conclusion: NE level can be used as a diagnostic indicator of acute exacerbation of asthma.