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近来,关于肝硬化所致食道静脉曲张的心得安疗效的研究已有报告。但是,鉴于其疗效问题尚无定论,适应证、给药方法,特别是高氨血症、低血糖等副作用尚未解决,故作者又进行了深入研究。对象是经腹腔镜及肝活检而确诊的肝硬化患者9例(男7例、女2例)。年龄为57.6±6.4岁,心得安用量为1日30mg(有1例为40mg),用药时间为16.4±5.7(6～25)周。对全部病例都定时测量心率及血压,3例在用药前及用药4周后测量了肝静脉楔入压(WH-
Recently, there have been reports on the propranolol efficacy of esophageal varices due to cirrhosis. However, in view of its curative effect, it is inconclusive. Indications, administration methods, especially side effects such as hyperammonemia and hypoglycemia have not yet been solved. Therefore, the author conducted further studies. Subjects were diagnosed by laparoscopy and liver biopsy in 9 patients with cirrhosis (7 males and 2 females). The age of 57.6 ± 6.4 years old, the amount of propranolol on the 1st 30mg (1 case of 40mg), medication time was 16.4 ± 5.7 (6 ~ 25) weeks. Heart rate and blood pressure were measured regularly in all cases, and hepatic venous wedge pressure was measured in 3 patients before treatment and 4 weeks after treatment (WH-