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硝普钠(Sodium Nitroprusside,Niprode)为一速效、短效,作用强的血管扩张剂,在临床上应用治疗高血压危象及改善心室功能均收到较好疗效。而硝普钠在血液中通过无酶反应,分解为氰化物,氰化物在肝中转化为硫氰酸盐(-SeN~-),后者基本无毒,最后经肾排出。硝普钠的代谢产物硫氰酸盐血浓度可作为出现毒性的指标。文献记载硫氰酸盐在10～12 mg/100ml 以下时病人能较好地耐受,故一般不应超过这一浓度。但个别患者的血中尚未达到这个浓度时,偶尔出现
Sodium Nitroprusside (Niprode) is a fast-acting, short-acting, and powerful vasodilator that has received good results in the clinical treatment of hypertensive crisis and improvement of ventricular function. The sodium nitroprusside in the blood through the enzyme-free reaction, decomposition of cyanide, cyanide in the liver into thiocyanate (-SeN ~ -), the latter basically non-toxic, and finally by the kidneys. Sodium nitroprusside metabolite thiocyanate blood concentration can be used as an indicator of toxicity. Documented thiocyanate in 10 ~ 12 mg / 100ml below the patient can better tolerate, it should generally not exceed this concentration. However, individual patients have not yet reached the blood concentration, occasionally