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目的：研究细胞粘附分子在肿瘤细胞的增殖，浸润、转移过程中的作用，其中ＣＤ４４分子是较受关注的。方法：采用免疫组化方法，检测ＣＤ４４变异体单抗（ＣＤ４４ｖ６单抗）及增殖细胞核抗原（ＰＣＮＡ单抗）在宫颈浸润癌及转移癌中的表达。发现两者在宫颈癌发生及淋巴结转移中呈明显过表达，阳性率分别是７８９％、８４２％。结果：ＣＤ４４ｖ６与肿瘤转移密切相关，发生淋巴结转移的宫颈原发癌组织同时伴有细胞增殖活性明显增高。结论：两者的协同检测可做为肿瘤转移判定的生物学指标。
Objective: To study the role of cell adhesion molecules in the proliferation, invasion and metastasis of tumor cells, of which CD44 molecules are of more concern. Methods: Immunohistochemistry was used to detect the expression of CD44 variant McAb (CD44v6 monoclonal antibody) and proliferating cell nuclear antigen (PCNA monoclonal antibody) in invasive cervical carcinoma and metastatic carcinoma. The results showed that both of them were over-expressed in cervical carcinogenesis and lymph node metastasis, the positive rates were 789% and 842% respectively. Results: CD44v6 was closely related to tumor metastasis. The primary cervical cancer with lymph node metastasis accompanied with significantly increased cell proliferation activity. Conclusion: The synergistic detection of both can be used as biological indicators of tumor metastasis.