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目的探讨支气管肺泡灌洗(BAL)对弥漫性间质性肺疾病(DILD)肺功能的影响。方法对25例DILD患者进行BAL,灌洗前和灌洗后进行肺功能检测。结果支气管肺泡灌洗后CO弥散量由灌洗前的(13.36±3.78)ml/min/mmHg下降至灌洗后(11.24±3.44)ml/min/mmHg,差异有统计学意义(P<0.05)。灌洗前后肺活量由(2.31±0.97)L下降至(2.02±0.85)L,肺总量由(3.55±1.09)L下降至(3.07±1.02)L,差异均无统计学意义(P>0.05)。1秒率灌洗前(83.5±6.52)%及灌洗后(83.8±6.28)%无动态改变。结论支气管肺泡灌洗可加重限制性通气障碍及弥散障碍,对气道阻塞无影响。
Objective To investigate the effects of bronchoalveolar lavage (BAL) on pulmonary function in patients with diffuse interstitial lung disease (DILD). Methods Twenty-five patients with DILD were tested for pulmonary function before and after lavage. Results The volume of CO diffusion after bronchoalveolar lavage decreased from (13.36 ± 3.78) ml / min / mmHg before lavage to 11.24 ± 3.44 ml / min / mmHg after lavage (P 0.05) . The lung volume decreased from (2.31 ± 0.97) L to (2.02 ± 0.85) L before and after lavage, and the total lung volume decreased from (3.55 ± 1.09) L to (3.07 ± 1.02) L, with no significant difference (P> 0.05) . There was no dynamic change in 1 second rate before lavage (83.5 ± 6.52)% and after lavage (83.8 ± 6.28)%. Conclusion Bronchoalveolar lavage can aggravate restrictive ventilatory and diffuse obstructions, and has no effect on airway obstruction.