论文部分内容阅读
目的:探讨哈萨克族心力衰竭(心衰)患者血浆和肽素(Copeptin)、N端前体脑钠肽(NT-proBNP)水平的变化及临床意义。方法:使用酶联免疫吸附测定法(ELISA)测定90例哈族心衰患者(心衰组)和30例同期住院哈族无心功能不全患者(对照组)的血浆Copeptin、NT-proBNP水平,超声心动图测量左房内径(LAD)、左室舒张末内径(LVEDD)、左室射血分数(LVEF)、左室短轴缩短率(FS)。结果:哈族心衰患者血浆Copeptin、NT-proBNP显著高于对照组,且随NYHA心功能分级的升高而升高,各组间差异具有统计学意义(P<0.01)。心衰患者Copeption、NT-proBNP具有相关性(r=0.692,P<0.01)。单因素分析显示,Copeption、NT-proBNP与LAD、LVEDD呈正相关(均P<0.01),与LVEF、FS呈负相关(均P<0.01)。在心衰组,分别将年龄、性别、NY-HA分级、超声心动图所测LAD、LVEDD、LVEF、EF、FS共8个因素行多元逐步回归分析,结果只有NYHA和LVEF是Copeptin、NT-proBNP的独立相关因素。结论:哈族心衰患者血浆Copeptin、NT-proBNP水平显著升高,并与心衰严重程度有良好的相关性。Copeptin、NT-proBNP可以作为判断哈族心衰患者心功能的一个良好指标。
Objective: To investigate the changes and clinical significance of Copeptin and NT-proBNP levels in Kazakh with heart failure (CHF). Methods: The plasma levels of Copeptin and NT-proBNP were measured by enzyme-linked immunosorbent assay (ELISA) in 90 Han nationality heart failure patients and 30 Han nationality patients with congestive heart failure (control group) Left atrial diameter (LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (FS) were measured by echocardiography. Results: The plasma Copeptin and NT-proBNP in Kazakh patients with heart failure were significantly higher than those in the control group, and increased with the increase of NYHA functional class. The differences among the groups were statistically significant (P <0.01). Copeption and NT-proBNP in patients with heart failure were correlated (r = 0.692, P <0.01). Univariate analysis showed that Copeption and NT-proBNP were positively correlated with LAD and LVEDD (all P <0.01), and negatively correlated with LVEF and FS (all P <0.01). In heart failure group, 8 factors including age, sex, NY-HA grade and echocardiography were used for multiple stepwise regression analysis. The results showed that only NYHA and LVEF were Copeptin, NT- ProBNP independent relevant factors. Conclusion: The plasma levels of Copeptin and NT-proBNP in Kazakh patients with heart failure are significantly increased, and have a good correlation with the severity of heart failure. Copeptin, NT-proBNP can be used as a good indicator of cardiac function in patients with heart failure.