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吸入β_2激动剂是治疗急性哮喘最有效的药物,此或许由于功能性拮抗许多哮喘介质所致。β_2受体功能的缺陷并非引起哮喘的原因,但β_2激动剂的治疗可引起肺外β受体功能的向下调节.并无确切证据表明,哮喘患者使用正常剂量的β_2受体激动剂后,会出现有临床重要意义的快速减敏,不过在规则治疗停药后12～23,小时可见有轻度的支气管激惹。对所有定期吸入β_2激动剂治疗者都应同时吸入激素,至少在成人中如此。激素并非仅仅消除支气管炎症和高敏,也有助于改善β_2受体的减敏状态。
Inhalation of beta 2 agonists is the most effective treatment for acute asthma, perhaps due to functional antagonism of many asthma mediators. The deficiency of β 2 receptor function is not the cause of asthma, but the treatment of β 2 agonist can cause down-regulation of extra-pulmonary β-receptor function.No conclusive evidence shows that asthma patients using normal dose of β 2 receptor agonist, There will be clinical significance of rapid desensitization, but after the regular treatment of drug withdrawal 12 to 23 hours can be seen with mild bronchial irritation. For all regular inhaled β 2 agonist treatment should be simultaneously inhaled hormones, at least in adults so. Hormones do not just eliminate bronchial inflammation and hypersensitivity, but also help to improve the desensitization of beta 2 receptors.