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IgA肾病是一类以肾小球系膜区弥漫性IgA沉积为特征的原发性肾小球肾炎。其临床表现多样化,预后相差甚远,组织学改变轻重不一,基本病变是肾小球系膜增殖。严格地说,IgA肾病并不是一个单一的疾病,而是具有共同免疫病理特征的一组症候群。自1968年Berger氏首次报告以来,对IgA肾病的临床病理特征、自然经过、预后、治疗及发病机理等诸多方面的认识均有很大进展。一、临床特征
IgA nephropathy is a type of primary glomerulonephritis characterized by diffuse IgA deposition in the mesangial area of the glomeruli. The clinical manifestations of diverse, far-reaching prognosis, histological changes in severity, the basic lesion is mesangial proliferation. Strictly speaking, IgA nephropathy is not a single disease, but a group of syndromes that share common immunopathological features. Since Berger’s first report in 1968, much progress has been made in understanding the clinicopathological features, natural history, prognosis, treatment and pathogenesis of IgA nephropathy. First, the clinical features