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目的了解龙岩市2008年EV71流行前后人群抗体水平,为防控手足口病提供依据。方法随机挑取2006年采集保存的1988年后出生人群血清160份,2009年采集正常人群血清90份,进行EV71的微量中和实验。结果 2008年以前人群EV71中和抗体阳性率、GMT水平和感染率分别为77.5%、1∶24.53和6.9%,提示EV71在2008年前已经在龙岩市存在局部流行。2008年后人群EV71中和抗体阳性率、感染率和GMT水平比流行前人群明显升高,但流行前后男女中和抗体阳性率、GMT水平和感染率差异均无统计学意义;流行前后5～9岁组中和抗体阳性率均高于0～4岁组。结论 2006年前EV71已存在并局部流行;5岁以下儿童是易感人群。
Objective To understand the antibody levels of human population before and after the EV71 epidemic in Longyan City in 2008 to provide basis for preventing hand-foot-mouth disease. Methods Totally 160 serum samples of post-1988 born and collected in 2006 and 90 serum samples of normal population were collected in 2006 for micro-neutralization of EV71. Results Before 2008, the positive rate of EV71 neutralizing antibody, the GMT level and the infection rate were 77.5%, 1:24.53 and 6.9%, respectively, suggesting that EV71 had been endemic in Longyan City before 2008. After 2008, the positive rate of EV71 neutralizing antibody, the infection rate and the GMT level were significantly higher than those before the epidemic, but there was no significant difference in the positive rate, GMT level and infection rate of the neutralizing antibody between male and female before and after the epidemic. The positive rates of neutralizing antibodies in 9 years old group were higher than those in 0 ~ 4 years old group. Conclusions EV71 has existed and is endemic before 2006; children under 5 years of age are susceptible.