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目的 探讨影响先天性心脏病室间隔缺损患儿血浆内皮素 - 1水平的因素及其临床意义。方法 选择 80例先天性心脏病室间隔缺损患儿 ,其中伴肺动脉高压者 5 2例 ,轻度肺动脉高压 18例 ,中度肺动脉高压 2 4例 ,重度肺动脉高压 10例。分别采取静脉血 ,用放射免疫法测定样品中内皮素 - 1含量。结果 室间隔缺损患儿血浆内皮素 - 1水平显著高于对照组 (P <0 0 1) ,且伴肺动脉高压者血浆内皮素水平较无肺动脉高压者明显增高 (P <0 0 1) ,血浆内皮素含量随肺动脉压力的升高而增加。结论 内皮素 - 1是先天性心脏室间隔缺损患儿肺动脉高压形成和发展的致病因素之一
Objective To investigate the factors that affect the plasma level of endothelin - 1 in children with congenital heart disease and its clinical significance. Methods Eighty children with congenital heart disease with ventricular septal defect were selected, including 52 with pulmonary hypertension, 18 with mild pulmonary hypertension, 24 with moderate pulmonary hypertension and 10 with severe pulmonary hypertension. Venous blood was taken and the content of endothelin - 1 in the samples was determined by radioimmunoassay. Results Plasma endothelin - 1 level was significantly higher in children with ventricular septal defect than those in control group (P <0.01). Plasma endothelin levels in patients with pulmonary hypertension were significantly higher than those without pulmonary hypertension (P <0.01) Endothelin levels increased with increased pulmonary artery pressure. Conclusions Endothelin - 1 is one of the causative agents for the formation and development of pulmonary hypertension in children with congenital heart ventricular septal defect