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目的：为评价洛赛克对肝源性溃疡（ＨＵ）的疗效。方法：对２５１例肝硬化经胃镜检出溃疡的４８例患者，予每日晨服洛赛克２０ｍｇ，疗程４～６周，着重观察胃镜下溃疡愈合情况，并与同期消化性溃疡（ＰＵ）疗效对比分析。结果：４周愈合率ＨＵ组中，十二指肠溃疡（ＤＵ）为６ ９．２％（１８／２６），胃溃疡（ＧＵ）为５２．９％（９／１７）；ＰＵ组中ＤＵ与ＧＵ均为１００％（３１／３１，６／６）．两组比较具有显著性差异（ Ｐ＜０．０１）。６周愈合率 ＨＵ中 ＤＵ为 ８４．６％（２２／２６），ＧＵ为 ８２．３％（１４／１７）。肝功能 ＣｈｉｌｄＣ级者溃疡愈合率明显降低。结论：洛赛克治疗ＨＵ疗效满意，但疗程宜较ＰＵ长。ＨＵ的愈合于Ｃ级患者较低。
Objective: To evaluate the efficacy of Losec in treating liver ulcer (HU). Methods: Forty-eight patients with liver cirrhosis who were diagnosed as ulcer by gastroscopy were treated with 20 mg daily morning service Losec for 4 to 6 weeks. The ulcer healing under the endoscopy was observed. The peptic ulcer (PU) Comparison of curative effect. Results: In the HU group, the duodenal ulcer (DU) was 62.2% (18/26) and the gastric ulcer (GU) was 52.9% (9/17) And GU were 100% (31 / 31,6 / 6). There was significant difference between the two groups (P <0.01). At 6 weeks, DU was 84.6% (22/26) in GU and 82.3% (14/17) in GU. Liver function ChildC grade ulcer healing rate was significantly reduced. Conclusion: Losec treatment of HU is satisfactory, but the treatment should be longer than PU. HU healing in patients with C-level lower.