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自然界中的一些物质(如骨)具有多重复杂分级结构,这种高度有序的微结构赋予了这些物质独特的近乎完美的综合性能。受此启发,制备具有仿生天然硬组织微结构的生物材料具有重要的意义。本文采用静电纺丝法成功制备出具有微结构的羟基磷灰石/明胶纳米复合纤维。探讨了明胶浓度、羟基磷灰石颗粒浓度和粒径对复合纤维形貌的影响,并对其牛血清白蛋白的吸附性能进行了讨论。研究结果表明,明胶浓度增大,纤维直径增大,其浓度过大会出现粘连现象,明胶浓度为15%纺丝较好;羟基磷灰石粒径为12μm,浓度为3%时的复合纤维为纳米级,纤维均匀。复合纤维的微结构是通过导电模板的拓扑结构来实现,研究发现纤维主要集中分布在图案化导电模板的棱上,实现了对复合纤维的有序调控即材料的结构设计。羟基磷灰石/明胶纳米复合纤维对牛血清白蛋白的吸附浓度主要取决于复合纤维的有效吸附面积,且牛血清白蛋白主要吸附在复合纤维的棱上。
Some substances in nature, such as bone, have multiple, complex hierarchical structures that give these materials a unique, near-perfect combination of properties. Inspired by this, the preparation of biological material with a bionic natural hard tissue microstructure is of great significance. In this paper, hydroxyapatite / gelatin nanocomposite fibers with microstructure were successfully prepared by electrospinning. The effects of gelatin concentration, hydroxyapatite particle concentration and particle size on the morphology of composite fibers were discussed. The adsorption properties of bovine serum albumin were also discussed. The results show that the gelatin concentration increases, the fiber diameter increases, the concentration of the conglutination occurs conglobation, gelatin concentration of 15% spinning better; hydroxyapatite particle size of 12μm, the concentration of 3% of the composite fiber is Nanometer, uniform fiber. The microstructure of the composite fibers is realized by the topological structure of the conductive template. It is found that the fibers are mainly concentrated on the edges of the patterned conductive template, which realizes the orderly control of the composite fibers, that is, the structural design of the material. The adsorption of bovine serum albumin by hydroxyapatite / gelatin nanofibers mainly depends on the effective adsorption area of the composite fibers, and the bovine serum albumin mainly adsorbed on the edges of the composite fibers.