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目的通过对胎膜早破孕妇患者阴道病原菌感染以及耐药性分析,为临床上合理性用药以及控制感染提供理论依据。方法回顾性分析5 138例胎膜早破孕妇患者的所有临床资料,进行常规性菌群与支原体培养以及衣原体的分析。结果 5 138例胎膜早破孕妇患者中检出阳性1 734例(易感率为33.7%);病原学阳性结果支原体培养为1 283例(占25.0%),衣原体测定为143例(占2.8%),细菌为941株(占18.3%),常见病原菌主要是革兰阴性菌329株(占35.0%),以大肠埃希菌为主;革兰阳性菌358株(占38.0%),以β-溶血性链球菌、肠球菌、溶血性葡萄球菌等为主;真菌254株(占27.0%),以白色念珠菌为主。常见的支原体、病原菌耐药性均较高。结论因胎膜早破孕妇患者常见的病原菌耐药性均较高,临床应依据药敏试验结果合理性用药。
Objective To analyze the vaginal pathogen infection and drug resistance of pregnant women with premature rupture of membranes and to provide theoretical basis for rational use of drugs and infection control in clinic. Methods All the clinical data of 5 138 pregnant women with premature rupture of membranes were retrospectively analyzed. The routine culture of bacteria and mycoplasma and the analysis of chlamydia were performed. Results A total of 1 734 cases (33.7%) were positive in 5 138 pregnant women with premature rupture of membranes. The number of mycoplasma positive cases was 1 283 (25.0%) and that of chlamydia was 143 (2.8 (Accounting for 18.3%). There were 329 common gram-negative bacteria (35.0%) in common pathogens, mainly Escherichia coli, 358 gram-positive bacteria (38.0%), β-hemolytic streptococcus, Enterococcus, Staphylococcus aureus and other mainly; 254 fungi (27.0%), mainly Candida albicans. Mycoplasma common, pathogenic bacteria were higher drug resistance. Conclusion Because of the high prevalence of pathogenic bacteria in pregnant women with premature rupture of membranes, the drug should be used rationally based on the results of drug sensitivity test.