Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong

• 作 者: Hao Li Xue-Liang Chen Hui-Qing Li
• 机 构: the Center of Tumour Treatment, Qilu Hospital of Shandong University, Jinan 250012, Shandong Provinc
• 出 处: 世界胃肠病学杂志（英文版）
• 发表日期: 2005年37期
• 关键词: Stomach cancer CYPIA1 GSTM1 Polymorphism

AIM: To explore whether polymorphisms of the CYPIA1 and GSTM1 genes are associated with susceptibility of stomach cancer.METHODS: A total of 102 stomach cancer cases and 62 healthy persons were diagnosed by pathology in 1998-2000 in the Qilu Hospital of Shandong University. Gene polymorphisms were detected by the PCR using sequence-specific primers. Data analysis of the case-control study was carried out using the unconditional logistic method.RESULTS: After adjustment for age, sex, educational levels, and occupation, the risk factors for stomach cancer were shown to be smoking, Helicobacter pylori(H pylori),and presence of the CYPIM G/G and GSTM1 O/O genotypes.Interaction was observed between the combined genotypes of either CYPIA1 G/G and GSTM1 O/O or H pylori infection,or GSTM1 O/O and H pylori infection or smoking.CONCLUSION: Polymorphisms of the CYPIA1 and GSTM1 genes, H pylori infection and smoking are related to susceptibility to stomach cancer.