论文部分内容阅读
日本静冈县立大学、东京大学等机构的一个联合研究小组2月17日宣布,在世界上首次弄清了导致蛀牙的葡聚糖蔗糖酶的立体结构。这一成果将有助于开发预防蛀牙的新方法和药物。蛀牙是在葡聚糖中生活的细菌分泌的酸腐蚀牙齿造成的。而口腔中的葡聚糖蔗糖酶能将糖转变成葡聚糖,形成易于细菌生存的环境。因此,抑制葡萄糖蔗糖酶的功能,将有效降低发生蛀牙的风险。葡萄糖蔗糖酶与分解淀粉的淀粉酶拥有类似的结构,此前研究人员一直不清楚二者的具体差异。研究小组通过人工方法大量制造出葡聚糖蔗糖酶,并成功使其结晶化,
A joint research group of Japan’s Shizuoka Prefectural University and the University of Tokyo announced on February 17 that for the first time in the world, the three-dimensional structure of dextran sucrase, which causes tooth decay, has been clarified. This result will help to develop new methods and medicines to prevent tooth decay. Tooth decay is caused by bacteria that secrete gluten that secrete acid that corrodes teeth. The dextran sucrase in the mouth can convert sugar into dextran, forming an environment that is easy for bacteria to survive. Therefore, inhibiting the function of glucose sucrase will effectively reduce the risk of tooth decay. Gluco-invertase has a similar structure to the amylase that breaks down starch, and it has not been clear to researchers until now for the specific differences between the two. The research team made a large number of glucan sucrase by artificial methods and successfully crystallized it,