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目的:评价降钙素原(procalcitionin,PCT)测定在重症感染诊疗中的应用价值。方法:以2011年1月~2016年1月,重症医学科收治的124例感染患者作为研究对象,常规治疗,在患者入院时、24h后、48h、72h,采血检测血清PCT,同时采用急性生理学和慢性健康状况评分系统(Acute physiology and chronic health evaluation,APACHEⅡ)进行危重评分评估,将重症患者纳入重症组,普通感染患者纳入普通组,重症组又分为有效亚组、无效亚组。结果:124例患者,其中54例进展为重症感染,治疗有效40例,无效14例;重症组无效亚组、合计亚组入院时、24h后、48h、72h后PCT高于普通组,无效亚组高于有效亚组,重症组24h后PCT水平相较于入院时、48后相较于入院时降幅低于有效亚组,差异具有统计学意义(P<0.05);PCT与APACHEⅡ呈正相关(r=0.842,P<0.05)。结论:PCT可作为重症感染诊断、疗效预测、严重程度评价依据。
Objective: To evaluate the value of procalcitionin (PCT) in the diagnosis and treatment of severe infections. Methods: From January 2011 to January 2016, 124 infected patients admitted to the Department of Critical Care Medicine were enrolled in this study. Normal patients were enrolled in the study. Serum PCT was detected at admission, 24 hours, 48 hours and 72 hours after admission. Acute physiology And chronic health evaluation system (Acute physiology and chronic health evaluation, APACHE Ⅱ). The critically ill patients were included in the severe group and the common ones were included in the common group. The severe cases were divided into the effective subgroup and the invalid subgroup. Results: 124 patients, of which 54 cases progressed to severe infection, the effective treatment of 40 cases, 14 cases of ineffective; severe group of invalid subgroups, the total subgroup at admission, 24h, 48h, 72h PCT was higher than the normal group, PCT group was significantly higher than APACHEⅡ (P <0.05), PCT group was significantly higher than APACHEⅡ (P <0.05), PCT group was significantly higher than APACHEⅡ r = 0.842, P <0.05). Conclusion: PCT can be used as a diagnosis of severe infection, efficacy prediction, severity evaluation basis.