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目的 :探讨全胃肠道促动力药物西沙必利对糖尿病性胃轻瘫 (DGP)的治疗作用。方法 :采用胃电图(EGG)体表描记法 ,分别描记DGP患者治疗前后及对照组EGG的数值 ,间接判断DGP患者治疗前后胃排空功能变化。结果 :治疗前DGP与对照组胃体、胃窦部的平均振幅 (AP)、峰值频率 (FP)均存在显著性差异 (P <0 .0 5或P <0 .0 1)。治疗后 2组比较 ,除胃窦AP外 ,胃体AP、FP及胃窦FP均无显著性差异 (P >0 .0 5 ) ,胃轻瘫患者的临床症状也得到显著改善。结论 :西沙必利是治疗DGP的有效药物。
Objective: To investigate the therapeutic effect of cisatapride on diabetic gastroparesis (DGP). Methods: EGG was used to describe the value of EGG before and after DGP treatment and control group, respectively. The changes of gastric emptying function before and after DGP were indirectly assessed. Results: The average amplitude (AP) and peak frequency (FP) of gastric body and gastric antrum in DGP group and control group before treatment were significantly different (P <0.05 or P <0.01). After treatment, there was no significant difference in gastric AP, FP and gastric antrum FP between the two groups except gastric AP (P> 0.05). The clinical symptoms of patients with gastroparesis were also significantly improved. Conclusion: Cisapride is an effective drug for the treatment of DGP.