【摘 要】
：
Tisplatin is one of the valuable icancer agents against several types of neoplasm. However, nephrotoxicity is the major adverse effect representing in cisplatin
【机 构】
：
Department of Veterinary Medicine, College of Agriculture, Yanbian University, Yanji 133000, Jilin,
论文部分内容阅读
Tisplatin is one of the valuable icancer agents against several types of neoplasm. However, nephrotoxicity is the major adverse effect representing in cisplatin therapy. In this study, the animal tests detecting protective effects of a natural compound, Decursin, on cisplatin-induced nephrotoxicity were examined by using in vivo model. Pretreatment Decursin 10, 20 and 40 mg · kg^-1 at 48, 24 and 6 h, and administration of a single dose of Cisplatin 5.2 mg · kg^-1. Nephrotoxicity was evaluated by serum BUN and creatinine examination. There was significant difference in body weights, serum BUN and creatinine levels of the normal group. Based on the new understanding of the protective mechanisms of cisplatin-induced nephrotocivity, new strategies can be developed to prevent renal injury or to enhance recovery after cisplatin treatment.
其他文献
棚里种的黄瓜、西红柿、茄子、辣椒等蔬菜,具有生长快、成熟早、产量高、经济效益好等优点.于是有些菜农就以为好种出好苗,好苗产量高,到大棚里选留菜种.其实,这是不可取的.
目的 探讨早产儿室环境照顾及护理.方法 改变新生儿室环境和照顾方式如物理环境和人文环境、减少声光刺激、减轻疼痛、给予舒适合理的体位、促进营养性吸吮行为的发育、适当
采用分层挖掘法对西藏特有灌木砂生槐（ Sophora moorcroftian）天然灌丛幼林根系进行取样，研究不同径级根系生物量、比根长和根长密度及垂直分布状况。研究结果表明：砂生槐总根系
The overwintering survival ratio of the cultivar Dongnongdongmai 1 with strong cold-resistance in paramos of Heilongjiang Province in China are over 85%. The ti
采用盆栽模拟涝渍环境的试验方法，研究了淹水胁迫对耐涝性不同的乌桕1年生实生苗的叶片质膜透性和渗透调节物质的影响。结果表明：与耐涝性强的浙江种源相比，耐涝性差的福建种源
国以农为本,农以种为先,种子是农业稳定和发展的坚定基石.对于关系到国计民生的种子行业,其管理者和经营者都有着更为重大的责任与义务.随着及相关办法的颁布和实施,种业市场
心律失常在儿科临床中常见.小儿心脏疾病及非心脏性疾病,如缺氧和水电解质紊乱等都可导致心律失常的发生.因此,对心律失常的正确诊断和治疗是儿科临床医师、尤其是小儿心血管
以南方泡桐（ Paulownia australis）二倍体及其同源四倍体幼苗为材料，分别采用AFLP和MSAP分子标记技术研究其DNA碱基序列及其甲基化的变化情况。研究结果表明：AFLP中平均每对引物
2009年7月17日,北京市科委主任闫傲霜一行到北京市农作物品种试验基地进行调研.闫傲霜主任首先考察了位于昌平区马池口镇的市级基地和昌平区基地,随后听取了北京市种子站赵山
According to our previous study, saprophytic fungi Botrytis cinerea contained 579 predicted secretary proteins. Among them, we found that 122 of these proteins