The unsulfated extracellular N-terminus of vGPCR reduces the tumorigenicity of hGRO-α in nude mice

• 作 者: WU Hui FU YongMing XIAO Jun ZH
• 机 构: KeyLaboratoryofProteinChemistryandDevelopmentalBiologyofMinistryofEducationofChina
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2013年1期
• 关键词: N-末端 硫酸化 致瘤性 裸鼠 NIH3T3 恶性肿瘤 肿瘤生长 G-蛋白 KSHV vGPCR hGRO-α sulfotyrosine tumori
• 基金项目: This work was supported by the National Natural Science Foundation of China （81171583, 31272634）, the Program for New Century Excellent Talents in University （NCET-11-0971）, the Scientific Research Fo

The Kaposi’s Sarcoma-associated Herpesvirus (KSHV)-encoded G-protein coupled receptor (vGPCR) is an oncoprotein that is implicated in KSHV-associated malignancies. We previously revealed vGPCR incorporates sulfate groups within its extracellular N-termina