Molecular Pharmacology of Antinicotinic Activity of Cholinolytic Drugs

• 作 者: 胡文祥 恽榴红
• 机 构: Institute of Pharmacology and Toxicology, AMMS, Beijing 100850, PRC,Institute of Pharmacology and To
• 出 处: Chinese Science Bulletin
• 发表日期: 1994年10期
• 关键词: poisoning classic AchR neurological institute hardly conformation isomers potent

Anticholinergic drugs have been widely used for many years in neurological researchand clinical therapy of many diseases, such as parkinsonism, stomachache and theorganophosphorus agents poisoning. But these drugs are antagonists of muscarinicreceptors(M-receptors) and can hardly be used in the treatment of soman poisoning,because it is known in our institute that the potent antimuscarinic and certainantinicotinic activities are necessary for a highly effective drug against Soman poi-soning. In our previous works, we developed a theoretical model for the drug-receptorinteraction deduced from a conformation-activity relationship (CAN) of classic agonists

Anticholinergic drugs have been widely used for many years in neurological research and clinical therapy of many diseases, such as parkinsonism, stomachache and theorganophosphorus agents poisoning. But these drugs are antagonists of muscarinic receptors (M-receptors) and can hardly be used in the treatment of soman poisoning, because it is known in our institute that the potent antimuscarinic and certainantinicotinic activities are necessary for a highly effective drug against Soman poi-soning. In our previous works, we developed a theoretical model for the drug-receptor interaction subtraced from a conformation-activity relationship (CAN) of classic agonists