【摘 要】
：
Objective: To determine the early outcomes of limb salvage surgery with mega prosthesis.Methods: This retrospective study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH&RC) from 1st January 2017 till 31st January 2020.
【机 构】
：
Surgical Oncology Department,Shaukat Khanam Memorial Cancer Hospital&Research Center,Lahore,Pakistan
论文部分内容阅读
Objective: To determine the early outcomes of limb salvage surgery with mega prosthesis.Methods: This retrospective study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH&RC) from 1st January 2017 till 31st January 2020. Data like demographics, histopathology, functional and survival outcomes were retrieved from the Hospital Information System. Musculoskeletal Tumor Society (MSTS) score was used to evaluate the functional outcomes after the surgery. For survival analyses, Kaplan-Meier curve was applied. Prosthesis joint infection, amputation rate, metastasis, mortality rate, and recurrence were also recorded. Results: This study included 43 patients who underwent limb salvage surgery with endoprosthesis reconstruction at SKMCH&RC. The mean age at the time of diagnosis was (26.5±15.8) years. Patients with distal femoral replacement had the highest MSTS scores (81.45±9.70) while those with proximal humerus replacement has the lowest MSTS scores (56.8±11.2). There was a strong association between site of tumor and MSTS (F=3.30, P=0.017). We also found a correlation between surgical site infection and MSTS scores (r=0.484, P=0.001). Patients with recurrence also had significantly lower MSTS scores (P<0.05). The cumulative survival rate at the end of two-year follow-up was (71.4±17.1)％ in proximal femur tumor patients, (88.0±7.8)％ in distal femur tumor patients, and (50.0±3.5)％ in proximal humerus tumor patients. Besides, patients with Ewing sarcoma had the highest survival rate (97.5±11.0)％ while patients with chondrosarcoma had the lowest survival rate (77.8±13.9)％. Conclusions: Limb salvage surgery with mega-prosthesis can be performed with satisfactory functional and survival outcomes, but further studies are needed to compare it with other limb salvage methods. This study can be used as a reference for future studies.
其他文献
克服特殊时期的困难和考验之后,《中华口腔正畸学杂志》完成换届工作,中华口腔正畸学杂志第三届编委会第一次会议于2021年6月11日在北京召开.来自全国25省市的66名编委和25名通讯编委参加了大会.
口腔粘接剂在牙体组织修复治疗中具有重要作用。通用粘接剂逐渐在口腔临床应用普及,它可以应用于不同的粘接模式,粘接多种材料,简化了粘接过程,提高了粘接效率。但由于牙本质的高蛋白和高含水量,通用粘接剂与牙本质的粘接仍然存在缺陷,许多研究正在寻找提高通用粘接剂与牙本质粘接性能的方法。本文旨在对如何提高通用粘接剂与牙本质粘接性能的方法进行综述。
目的使用微种植支抗矫治成人骨性Ⅱ类突面型，观察矫治前后矢状向牙齿突度和唇突度变化。方法选取36例治疗结束的成人骨性Ⅱ类突面型患者，所有患者均是拔除4颗第一前磨牙使用自攻型微种植体作为支抗内收前牙。对治疗前、后头颅侧位片进行测量分析。结果36例患者的切牙、软组织等测量指标发生显著性变化，上切牙内收(5.98±3.82) mm，下切牙内收(4.95±3.89) mm，上唇突度减少(3.5±2.40)
即刻种植以其独特的优势广泛应用于临床实践。然而美学区即刻种植,不仅高度复杂,还具有极大的美学风险。在美学区进行即刻种植时对适应症的选择、手术操作方式以及医生的临床技能有更高的要求。本文对有利和不利条件下美学区即刻种植的相关文献、共识化意见及推荐的临床方案进行了总结和探讨,以期为临床病例的决策、设计和解决提供参考。
Objective: To compare the value of HEART and TIMI scores in predicting major adverse cardiovascular events (MACEs) of patients with chest pain in the emergency department at a tertiary care hospital in Ahmedabad, a city in western India. Methods: A prospe
目的:探讨尼古丁对大鼠结合上皮(junctional epithelium,JE)根向迁移的影响。方法:20只6周龄雄性Wistar大鼠随机等分为实验组(每日腹腔注射尼古丁0.73 mg/kg)和对照组(每日腹腔注射等量生理盐水),每组再等分为30 d和90 d两个亚组;按实验设计处死后,常规制作右侧下颌磨牙区牙体-牙周联合组织的近远中向石蜡切片,Masson染色;测量第一磨牙釉牙骨质界-JE根端的长度。SPSS 26.0统计软件下各组数据行独立样本t检验。结果:30 d实验组和对照组相比,实验组大鼠JE
Objective: To determine the characteristics and risk factors of drug dependence among patients who were administered drugs with addictive potential (DAP) in an emergency department (ED).Methods: This retrospective cross-sectional study included patients w
目的:通过对致密性成骨不全(pycnodysostosis)继发颌骨骨髓炎病例回顾性分析及手术方式探讨,提高此类疾病的临床诊疗水平。方法:对2013年6月~2015年6月桑给巴尔Nnazi Mmoja医院收治的致密性成骨不全继发颌骨骨髓炎患者进行回顾性分析,总结患者的临床病史、影像学资料、治疗方法及随访资料。结果:共有5例患者诊断为致密性成骨不全继发颌骨骨髓炎,经过合理的抗生素治疗及颌骨病灶死骨搔刮或切除后,患者红细胞沉降率、C反应蛋白及血常规均恢复正常,随访12~24个月,临床治愈率80%(4/5),复
牙周内窥镜是微创的牙周非手术治疗方法,其使用相比传统SRP可以取得更好的临床效果.现本文报告了1例Ⅲ期B级牙周炎伴有错牙合畸形(安氏Ⅱ类)的患者基础治疗后仍有较多深牙周袋(PD≥5 mm),辅助牙周内窥镜治疗后正畸治疗取得良好效果的病例.
目的:探讨Ca2+对人牙囊细胞(hDFCs)成骨分化的影响及其分子机制。方法:分离培养hDFCs,免疫荧光染色及流式细胞术检测hDFCs的来源。反转录聚合酶链反应(RT-PCR)检测L型钙通道、T型钙通道、三磷酸肌醇受体以及雷诺定受体在hDFCs的表达及-成骨分化相关基因RUNX相关转录因子2(runt-related transcription factor 2,RUNX2)、骨钙素(osteocalcin,OCN)的表达。茜素红染色分别检测移除细胞外Ca2+