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目的观察小剂量奥美拉唑治疗慢性非萎缩性胃炎的临床效果。方法选取2003—2012年广东省黄村体育训练中心门诊部收治的慢性非萎缩性胃炎患者280例,将其按照随机数字表法分为对照组80例和治疗组200例。对照组采用法莫替丁片治疗,治疗组在对照组基础上加用小剂量奥美拉唑治疗,两组均治疗14 d。观察两组患者治疗后临床症状缓解率,并比较两组疗效和不良反应发生率。结果对照组临床症状缓解率为90.0%(72/80),低于治疗组的93.0%(198/200)(P<0.05)。对照组总有效率为85.0%(68/80),低于治疗组的98.5%(197/200)(P<0.05)。对照组不良反应发生率为8.8%(7/80),高于治疗组的2.0%(4/200)(P<0.05)。结论小剂量奥美拉唑治疗慢性非萎缩性胃炎,可有效改善患者的胃黏膜组织病变和胃部灼热感、反酸症状,促进患者康复,减轻其痛苦,此外,不良反应少,具有安全性高和治疗效果好等优点。
Objective To observe the clinical effect of low-dose omeprazole in the treatment of chronic non-atrophic gastritis. Methods Two hundred and eighty patients with chronic non-atrophic gastritis were enrolled in the Outpatient Department of Huangcun Physical Training Center from 2003 to 2012. They were divided into control group (n = 80) and treatment group (n = 200) according to random number table. The control group was treated with famotidine, the treatment group was treated with small-dose omeprazole on the basis of the control group, and both groups were treated for 14 days. The clinical symptom relief rate was observed after treatment in both groups, and the curative effect and incidence of adverse reactions were compared between the two groups. Results The rate of clinical symptom relief was 90.0% (72/80) in the control group, which was lower than 93.0% (198/200) in the treatment group (P <0.05). The total effective rate in the control group was 85.0% (68/80), which was lower than 98.5% (197/200) in the treatment group (P <0.05). The incidence of adverse reactions in the control group was 8.8% (7/80), which was higher than 2.0% (4/200) in the treatment group (P <0.05). Conclusion Low-dose omeprazole in the treatment of chronic non-atrophic gastritis can effectively improve gastric mucosal tissue lesions and gastric burning sensation, acid reflux symptoms, promote patient rehabilitation and reduce their pain, in addition, less adverse reactions, with safety High and good therapeutic effect.