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利用离体兔肝细胞为模型，对肝细胞刺激因子（ＨＳＳ）及清开灵抗ＣＣｌ_４肝损伤机制进行了研究，结果表明：清开灵可明显增强ＣＣｌ_４染毒前后细胞色素Ｐ—４５０含量与活性，可降低细胞内过氧化脂质（ＬＰＯ）含量，促进肝细胞增殖，因此对ＣＣｌ_４造成的肝损伤具有保护作用；ＨＳＳ对影响ＣＣｌ_４代谢的酶─—细胞色素Ｐ—４５０及ＣＣｌ_４代谢产物──ＬＰＯ均无作用，但它有较强的促细胞增殖作用。
Using isolated rabbit hepatocytes as a model, we studied the mechanism of hepatocyte stimulating factor (HSS) and CCl 4-induced hepatic injury in Qingkailing. The results showed that Qingkailing could obviously increase the content of cytochrome P-450 Activity, can reduce intracellular lipid peroxide (LPO) content, and promote liver cell proliferation, and therefore have a protective effect on liver damage caused by CCl_4; HSS on CCl_4 metabolism of enzymes ─-cytochrome P-450 and CCl_4 metabolites ─ ─LPO no effect, but it has a strong role in promoting cell proliferation.