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Hydrodynamic optimization design of the bend pipe from pump using the Navier-Stokes solver and evolutionary algorithms was conducted. The minimization of the total pressure loss of the bend pipe was chosen as the design object in order to obtain the uniform exit flows through suppressing the secondary flows. The 3-D Navier-Stokes solver was applied to evaluate the hydrodynamic performance of the bend-pipe flows. A 7th-order Bezier curve was used to parameterize the meridional section and elliptic representation was adopted to represent the cross-section profiles of the bend pipe. Evolutionary algorithms were applied in optimization. The obtained results show that the designed bend pipe shape has much more uniform exit flows compared with the initial one and much weaker secondary flows, and that the evolutionary algorithms and CFD technique are the powerful optimization tools for the fluid machinery design.