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我们于1988年开始采用激素撤除并用阿糖腺苷治疗慢性乙型肝炎20例。报告如下。材料与方法一、病例选择住院病人20例,年龄23～42岁,男性13例,女性7例。慢性活动型肝炎(下称慢活肝)11例,慢性迁延型肝炎(下称慢迁肝)9例。均按南宁全国肝炎会议诊断标准,肝活组织检查确诊。治疗前,HBsAg,HBeAg和HBV-DNA持续阳性半年以上。二、治疗方法先口服强的松40mg/日,共10日,继以强的松30mg/日,10日,再用强的松20mg/日,10日,共30日,停药后给予阿糖腺苷600mg/日及400mg/日,分别为7日及14日,静脉缓慢滴入,同时加用齐墩果酸、肌苷及维生素等保肝药物。三、观察指标按照卫生部颁发抗肝炎药物临床指导原则(试行),用药前检测肝功能:包括GPT、GOT、
We started in 1988 with hormone withdrawal and treatment of 20 cases of chronic hepatitis B with adenosine. The report is as follows. Materials and methods First, the patient selected 20 cases of patients, aged 23 to 42 years old, 13 males and 7 females. Chronic active hepatitis (hereinafter referred to as slow-living liver) in 11 cases, chronic persistent hepatitis (hereinafter referred to as slow-moving liver) in 9 cases. According to Nanning National Hepatitis Conference diagnostic criteria, liver biopsy confirmed. Before treatment, HBsAg, HBeAg and HBV-DNA continued to be positive for more than six months. Second, the treatment First oral prednisone 40mg / day, a total of 10, followed by prednisone 30mg / day, 10, and then prednisone 20mg / day, 10 days, a total of 30 days after giving medicine Glucobalamin 600mg / day and 400mg / day, respectively, on the 7th and 14th, intravenous drip slowly, while adding oleanolic acid, inosine and vitamins and other liver protection drugs. Third, the observation indicators In accordance with the clinical guidelines issued by the Ministry of Health anti-hepatitis drugs (Trial), liver function test before treatment: including GPT, GOT,