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Dear Editor,rnThe pathophysiological mechanisms underlying mood disorders including major depressive disorder(MDD)remain to be fully characterized.Iron is a key component in the development of the central nervous system and iron deficiency has been linked to impairments of mood and cognition[1].Recent studies have reported an inverse association between iron uptake and the risk of depression,as MDD patients have a reduced serum concentration of iron[2].Moreover,few investigations have monitored the symptoms of MDD patients with iron supplementation.Evidence for effects of increased iron on cognitive disorders is scarce,although treatment of small group of psychiatric patients with an iron chelator apparently led to clinical improvement[3].