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应用药物在各环节选择性阻断血栓烷(TX)的合成从而治疗或预防脑血管病。目前认为糖皮质激素和各种钙离子拮抗剂是通过抑制磷脂酶 A_2而抑制 TX 合成后发挥效应。阿司匹林的应用现主张小剂量(40mg/d)隔日疗法,女性似应较男性患者使用更大剂量。大量动物试验表明,应用 TX 合成酶抑制剂不仅阻断 TX 的合成,还促进前列环素的产生,故疗效更佳。前列环素已能有效地治疗缺血性脑血管病。
Application of drugs in various aspects of selectively blocking thromboxane (TX) synthesis in order to treat or prevent cerebrovascular disease. Currently, glucocorticoids and various calcium antagonists exert their effects by inhibiting TX synthesis by inhibiting phospholipase A2. Aspirin applications now advocate a small dose (40mg / d) every second day of treatment, women should be used than men to use larger doses. A large number of animal experiments show that the use of TX synthase inhibitors not only block the synthesis of TX, but also promote the generation of prostacyclin, so the effect is better. Prostacyclin has been effective in the treatment of ischemic cerebrovascular disease.