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唑尼沙胺(Zonisamide,3-sulfamoylmethyl-1,2-benzisoxazole,ZNS)的确切作用机制尚不清楚,似乎是通过阻断癫痫放电的传播和抑制引起癫痫病灶活动而发挥作用。临床上,ZNS最初用于简单和复杂部分性发作以及继发性全身强直一阵挛性发作。最近,有人报导了数例婴儿痉挛(IS的)患儿使用ZNS有效。但对多数患儿而言,ZNS仍仅作为联合治疗用药。本研究目的是确定ZNS单药治疗新诊断的IS的患儿的短期疗效。 收集了1995年1月～1996年1月间,住院治疗的13例新诊断为IS的病儿。所有病儿临床上均有典型的痉挛、智力迅速恶化,EEG示高峰节律紊乱或变异高峰
The exact mechanism of action of Zonisamide (ZNS) is not clear and appears to work by blocking the spread of epileptiform discharges and inhibiting the activity of epileptic foci. Clinically, ZNS was originally used for simple and complex partial seizures and secondary tonic-tonic seizures. Recently, it has been reported that several cases of infantile spasms (IS) are effective with ZNS. However, for most children, ZNS is still only used as a combination therapy. The aim of this study was to determine the short-term efficacy of ZNS monotherapy in newly diagnosed children with IS. Thirteen newly diagnosed children with IS were hospitalized from January 1995 to January 1996. All sick children are clinically typical spasms, rapid deterioration of intelligence, EEG showed peak rhythm disorder or peak variation