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杂环合成,日益趋向于一个分子中包括多种结构,也许正是由于不同杂环,非杂环在同一分子中聚集,共同促进了杂环化合物与有机体中细胞上微子结构结合,使其呈现出多样生物活性。例如,1,3,4—噻二唑和1,2,4—均三唑,它们是两类不同类型的五员杂环,分别具有抗菌、杀虫、除草、植物生长调节旧等活性。若将两类杂环稠合制得 3.6—二取代三唑并噻二唑类衍生物,则这类稠杂环除保留原有的一些生物活性外,还表现出消炎、抗微生物等药理性质。
Heterocyclic synthesis, increasingly tend to include a variety of molecular structure, perhaps because of different heterocycles, non-heterocyclic in the same molecule aggregation, together to promote the heterocyclic compounds and organism cells in the micro-structure binding, making it Showing a variety of biological activity. For example, 1,3,4-thiadiazole and 1,2,4-triazole, which are two different types of five-membered heterocyclic ring, respectively, with antibacterial, insecticidal, weeding, plant growth regulating the old activity. If the two kinds of heterocycles are fused to produce 3.6-disubstituted triazolothiadiazole derivatives, the fused heterocycles will exhibit anti-inflammatory, anti-microbial and other pharmacological properties in addition to some original biological activities .