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目的探讨人附睾上皮细胞分泌蛋白4(HE4)与CA-125联合检测在卵巢癌中的表达的价值。方法用罗氏Cobs e601电化学发光方法检测HE4与CA-125共计118例,其中盆腔良性肿瘤和恶性肿瘤共82例。结果 82例患者使用HE4和CA-125联合检测在诊断卵巢癌中的敏感性和特异性分别为66.7%、91.7%,均高于单一CA-125检测在诊断卵巢癌中的敏感度和特异性50%、75%,P<0.05,差异有统计学意义。结论 HE4和CA-125联合检测在卵巢癌的诊断中的敏感度和特异性,均高于单一CA-125检测,有助于卵巢癌的诊断、治疗监测。
Objective To investigate the expression of human epididymal epithelial cell-secreting protein 4 (HE4) and CA-125 in ovarian cancer. Methods Roche Cobs e601 electrochemiluminescence method was used to detect HE4 and CA-125 in 118 cases, of which there were 82 cases of pelvic benign and malignant tumors. Results The sensitivity and specificity of the combined detection of HE4 and CA-125 in 82 patients with ovarian cancer were 66.7% and 91.7%, respectively, which were higher than those of single CA-125 in diagnosing ovarian cancer 50%, 75%, P <0.05, the difference was statistically significant. Conclusion The sensitivity and specificity of the combined detection of HE4 and CA-125 in the diagnosis of ovarian cancer are higher than the single CA-125 test, which is helpful for the diagnosis and treatment monitoring of ovarian cancer.