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①目的探讨肺鳞癌间质血管生成的意义。②方法应用ＦⅧ相关抗原并采用ＳＬＡＢ法对８９例手术切除的肺鳞癌间质内微血管进行了定量检测。③结果癌间质内微血管呈明显的多态性；血管的分布每２００倍视野在癌肿边缘区组织内为５２．４±２３．７个，在癌组织中央区为３０．５±１３．６个，两组间比较差异有极显著性（ｔ＝４．１８，Ｐ＜０．０１）；有淋巴结转移组肺癌血管密度每２００倍视野５０．２±２２．８个，无转移组为３４±１９．１个；有转移组微血管腔面积每２００倍视野为３４５０．４±１４２１．９μｍ２，无转移组为２００１．０±１２０２．０μｍ２，二者在两组间比较，差异均有极显著性意义（ｔ＝３．１７，ｔ＝３．５８，Ｐ均＜０．０１）。④结论肺鳞癌间质内血管生成与肿瘤生长及淋巴结转移有关。
Objective To investigate the significance of angiogenesis in lung squamous cell carcinoma. 2 Methods FVIII-associated antigens were used and SLAB method was used to quantify 89 surgically resected interstitial microvessels in lung squamous cell carcinoma. 3 Results There were significant polymorphisms in intratumoral microvessels; the distribution of blood vessels was 52.4±23.7 in the marginal tissue of the cancer in each 200-fold field, and 30.5±13 in the central area of the cancer. Among the 6 groups, the difference between the two groups was highly significant (t=4.18, P<0.01); in the group with lymph node metastasis, the vascular density of lung cancer was 50.2±22.8 per 200-fold field of vision; the non-metastasis group was 34±19.1; the microvessel lumen area of the metastatic group was 3450.4±1421.9μm2 per 200-fold field, while the non-metastasis group was 2001.0±1202.0μm2. The difference was significant between the two groups. Significant significance (t=3.17, t=3.58, P all <0.01). 4 Conclusion Interstitial angiogenesis in lung squamous cell carcinoma is related to tumor growth and lymph node metastasis.