Astrocytic modulation of potassium under seizures

• 作 者: Fushun Wang Xiaoming Qi Jun Zh
• 机 构: DepartmentofNeurosurgery,InstituteofBrainandPsychologicalScience,DepartmentofNeurosurgery,Department
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2020年6期
• 关键词: AQP4 Ca^2+ signaling cell volume CONNEXINS EPILEPSY K^+ BUFFERING mi RNA NKCC PA
• 基金项目: supported partially by Helen Vosburg Mc Crillus Plummer,Robert Edward Lee Plummer,Jr.Chair in Neurosurgery(to JHH),NIH-R01-NS-067435(to JHH).

The contribution of an impaired astrocytic K^+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade.A defective K^+ regulation leads to an elevated extracellular K^+ concentration([K^+]o).When[K^+]o