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1974年夏秋季,我组在热区执行救治任务,对微循环障碍与脑型疟发生、发展的联系做了初步探索,并对山莨菪碱(654或654-2)的治疗效果进行了观察,现介绍如下。我们救治的病例都是1～5岁的小儿,高热30.4～40.9℃不等,血压106～130/70～90毫米汞柱,均出现深浅不同程度的昏迷或意识障碍,瞳孔缩小,对光反应迟钝,划跖试验阳性,腹壁、提睾反射消失,肝脾不同程度的肿大,有的出现颈强直和呕吐。昏迷前,有烦躁,惊厥和抽搐,有的达10次之多。血中恶性疟环状体4,000～50,000/立方毫米,有1例达80万个。
In the summer and autumn of 1974, our group performed the rescue task in the hot zone and made preliminary exploration on the relationship between microcirculation disorder and the occurrence and development of cerebral malaria. The therapeutic effect of anisodamine (654 or 654-2) was also observed Now introduced as follows. We are the treatment of cases are 1 to 5-year-old children, high fever 30.4 ~ 40.9 ℃, blood pressure 106 ~ 130/70 ~ 90 mm Hg, there are varying degrees of coma or unconsciousness, miosis, photoreactions Delayed, planted test positive, abdominal wall, cremasteric reflex disappeared, liver and spleen to varying degrees of swelling, and some appear neck stiffness and vomiting. Before coma, irritability, convulsions and convulsions, and some as many as 10 times. Blood malaria ring 4,000 to 50,000 / cubic mm, a case of 800,000.