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糖尿病性肾病(DN)是糖尿病晚期并发症之一。一般认为胰岛素依赖型糖尿病(IDDM)发病后5至10年即有30%～50%的患者并发 DN,而尿中自蛋白排出增加是肾病的早期表现。为研究患者长期血糖控制情况与 DN 的关系,作者自1983年开始对100例 IDDM 患者(男42,女58)进行前瞻性研究。患者年龄18.6±3.6岁(10～29岁),糖尿病病程12.1±3.5年(8.1±23.7年),每年测
Diabetic nephropathy (DN) is one of the advanced complications of diabetes. It is generally accepted that 30% to 50% of patients with insulin-dependent diabetes mellitus (IDDM) develop DN between 5 and 10 years, whereas increased urinary protein excretion is an early manifestation of nephropathy. To study the relationship between long-term glycemic control and DN in patients, the authors conducted a prospective study of 100 IDDM patients (male 42, female 58) since 1983. Patients aged 18.6 ± 3.6 years (10-29 years), duration of diabetes 12.1 ± 3.5 years (8.1 ± 23.7 years), measured annually