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目的 :探讨不同血糖水平者胰岛 β细胞分泌激素中真胰岛所占的比率 ,为临床治疗糖尿病提供指导。方法 :测定糖耐量正常 (NGT)、糖耐量低减 (IGT)和 2型糖尿病 (2TDM)者空腹及餐后 2小时免疫活性胰岛素及真胰岛素浓度并计算比值 ,分析该比值与 β细胞功能的关系。结果 :真胰岛素与免疫活性胰岛素的比值大小依次为 :NGT组 >IGT组 >2TDM组 (P <0 0 1) ;真胰岛素与免疫活性胰岛素比值变化与 β细胞功能变化相似。结论 :免疫活性胰岛素不能客观反映胰岛 β细胞分泌功能 ,所谓的“高胰岛素血症”可能是高前胰岛素血症
Objective: To investigate the ratio of true islets in the secretion of pancreatic β-cells in different blood glucose levels, providing guidance for the clinical treatment of diabetes mellitus. METHODS: Fasting and postprandial 2-hour immunocompetent insulin and true insulin concentrations were measured in normal glucose tolerance (IGT), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM), and ratios were calculated. The ratio was compared with β-cell function relationship. Results: The ratios of true insulin to immunologically active insulin were as follows: NGT group> IGT group> 2TDM group (P <0.01). The ratio of true insulin to immunocompetent insulin was similar to that of β-cell function. Conclusion: Immune active insulin can not objectively reflect pancreatic β-cell secretory function. The so-called “hyperinsulinemia” may be hyperinsulinemia