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对天狮营养高钙素的毒性、致突变性和致畸性进行了研究,结果表明小鼠和大鼠的LD_(50)大于10g/kg,属于实际无毒;大鼠30d喂养试验中,各剂量组动物未见异常、中毒症状和死亡,血液学检查,红细胞、白细胞及血红蛋白值均在正常范围之内,生化检验,各项指标均在正常范围之内;食物利用率除高剂量组雄性动物低于正常对照组(差异有显著性)外,其它剂量组与对照组相比均无显著性差别,脏体比值及病理学检查均属正常;三项致突变实验(Ames实验、小鼠骨髓细胞微核实验和小鼠生殖细胞染色体畸变实验)均为阴性反应;致畸实验中,未见胚胎毒性及胎鼠畸变发生。该品作为保健食品服用是相对安全的。
The toxicity, mutagenicity and teratogenicity of TSP nutrition were studied. The results showed that the LD_ (50) of mice and rats was more than 10g / kg, which was actually non-toxic. In the 30d feeding experiment, The animals in the dose group showed no abnormalities, symptoms and death of poisoning, hematological examination, erythrocytes, white blood cells and hemoglobin values were within the normal range, biochemical tests, the indicators were within the normal range; the food utilization rate in addition to high-dose group of males Animals were lower than the normal control group (the difference was significant), the other dose group compared with the control group no significant difference, the ratio of dirty body and pathological examination are normal; three mutagenic experiments (Ames test, mice Bone marrow micronucleus test and mouse germ cell chromosome aberration test) were negative reaction; teratogenic experiments, no embryonic toxicity and fetal rat aberrations occurred. The product as a health food is relatively safe to take.