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目的观察慢性阻塞性肺疾病(COPD)患者血清甲状腺激素水平的变化及临床意义。方法将所选对象分3组,即COPD急性发作组、缓解组(为急性发作组患者经治疗缓解后)、对照组(同时期因其他疾病住院的患者,经检查除外呼吸系统疾病以及影响心肺功能的疾病)。采用放射免疫分析法测定3组患者血清三碘甲状腺原氨酸(FT3)、四碘甲状腺原氨酸(FT4)、促甲状腺激素(TSH)水平,进行比较。结果COPD急性发作期患者血清FT3、FT4均显著下降,与对照组比较,P<0.05,差异有统计学意义。治疗后病情缓解者上述参数明显上升,与急性发作期患者比较,P<0.05,差异有统计学意义。治疗后缓解期与对照组比较,P>0.05差异无统计学意义。各组间TSH比较,P>0.05差异无统计学意义。结论COPD急性发作期患者血清甲状腺激素水平减低,其变化与疾病的严重性有关,观察其变化,对判断病情及预后具有一定的临床意义。
Objective To observe the changes of serum thyroid hormones in patients with chronic obstructive pulmonary disease (COPD) and its clinical significance. Methods The subjects were divided into 3 groups: acute exacerbation group, remission group (after exacerbation of acute exacerbation group), control group (patients hospitalized for other diseases during the same period, except for respiratory system diseases, Functional disease). The levels of serum triiodothyronine (FT3), tetraiodothyronine (FT4) and thyroid stimulating hormone (TSH) were measured by radioimmunoassay in three groups. Results The serum levels of FT3 and FT4 in patients with acute exacerbation of COPD were significantly decreased, P <0.05 compared with the control group, the difference was statistically significant. After treatment, the above parameters of patients with remission were significantly increased, compared with patients with acute exacerbation, P <0.05, the difference was statistically significant. After treatment, compared with the control group, there was no significant difference in P> 0.05. TSH between the groups, P> 0.05 no significant difference. Conclusion Serum thyroid hormone level is decreased in patients with acute exacerbation of COPD. The changes are related to the severity of the disease. To observe the changes is of clinical significance in judging the condition and prognosis.