论文部分内容阅读
本文合成、表征了乙二胺、1,3-丙二胺和1,2-丙二胺桥联邻菲咯啉配体及其镧髥配合物,研究了配合物对人白血病HL60、人前列腺癌PC-3MIE8、人胃癌BGC-823、人乳腺癌MDA-MB-435、人肝癌Bel-7402、人宫颈癌Hela等6个瘤株的体外抗肿瘤活性及其与DNA的作用方式,结果表明该系列化合物对实验的6种瘤株均具有明显的生长抑制作用,具有广谱性。其作用机理可能是配合物以部分插入方式,同时伴随共价作用与静电作用与DNA发生作用,进而影响基因调控与表达,抑制肿瘤细胞的生长,最终导致癌细胞的凋亡。
In this paper, ethylenediamine, 1,3-propanediamine and 1,2-propanediamine bridged phenanthroline ligands and their complexes were synthesized and characterized. The effects of the complexes on human leukemia HL60, human prostate In vitro antitumor activity of 6 cancer cell lines including PC-3MIE8, human gastric cancer BGC-823, human breast cancer MDA-MB-435, human liver cancer Bel-7402 and human cervical cancer Hela, and their interaction with DNA This series of compounds on the experimental 6 kinds of tumor strains have obvious growth inhibitory effect, with a broad spectrum. Its mechanism of action may be part of the complex insertion method, accompanied by covalent and electrostatic interactions with the role of DNA, thus affecting gene regulation and expression, inhibition of tumor cell growth, and ultimately lead to apoptosis of cancer cells.