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人类胎盘催乳素(HPL)和妊娠特异β-1-糖蛋白(SP_1)由胎盘的合体细胞层产生,故可反映胎盘功能。甲胎蛋白(AFP)由胎儿肝脏和卵黄囊产生,血清AFP水平低可能由于无胚胎性妊娠或死胎;血清AFP值升高可能因神经管缺陷或胎儿异常所致。本文对孕6-9周因阴道出血住院妇女共109例作血清HPL、SP_1和AFP测定。入院首次、住院期间每周两次以及出院后10-14天做血清激素测定,计算其对流产的预告性价值(%)。109例先兆流产孕妇中有51例(47%)流产、58例(53%)继续妊娠到分娩。血清HPL、SP_1和AFP首次测定值的流产预告率分别为91.7%、75.9%和81.8%,而预告妊娠成功率分别为68.7%、73.6%和65.4%。
Human placental prolactin (HPL) and gestational-specific beta-1-glycoprotein (SP_1) are produced by the placental syncytial cell layer and thus reflect placental function. Alpha-fetoprotein (AFP) is produced by the fetal liver and the yolk sac. Low levels of serum AFP may be due to non-embryo pregnancies or stillbirths; elevated serum AFP levels may be due to neural tube defects or fetal abnormalities. In this paper, a total of 109 pregnant women with vaginal bleeding from 6 to 9 weeks were measured serum HPL, SP_1 and AFP. Admission for the first time, twice a week during hospitalization and 10-14 days after discharge to do a serum hormone test, calculate the value of its forenotice (%) on abortion. In 109 cases of threatened abortion pregnant women, 51 cases (47%) abortion, 58 cases (53%) to continue pregnancy to childbirth. The first forensic value of serum HPL, SP_1 and AFP were 91.7%, 75.9% and 81.8%, respectively, while the predictive rates of pregnancy were 68.7%, 73.6% and 65.4%, respectively.