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目的探讨神经肽Ｙ（ＮＰＹ）在老年人高血压心律失常中的作用及培哚普利对心律失常的影响。方法放免分析法测定８０例老年人高血压患者培哚普利干预前后血中ＮＰＹ的含量，并用动态心电图、超声心动图了解治疗前后心律失常、心肌缺血和心肌肥厚程度的状况。结果左室肥厚组、心肌缺血组患者血ＮＰＹ浓度明显高于相应的对照组，并且血中ＮＰＹ浓度与左室肥厚程度、心肌缺血时间正相关。培哚普利在降低血ＮＰＹ浓度、减少心律失常发生的同时，伴有心肌肥厚程度和心肌缺血时间缩短，相关分析亦发现ＮＰＹ下降程度与心肌肥厚减轻和缺血时间缩短正相关。结论ＮＰＹ含量减少在血管紧张素化酶抑制剂作用过程中起到一定的作用
Objective To investigate the effect of neuropeptide Y (NPY) on arrhythmia in elderly patients and the effect of perindopril on arrhythmia. Methods Radioimmunoassay was used to determine the level of NPY in 80 elderly hypertensive patients before and after treatment with perindopril. The changes of arrhythmia, myocardial ischemia and myocardial hypertrophy before and after treatment were observed by dynamic electrocardiogram and echocardiography. Results The plasma levels of NPY in left ventricular hypertrophy group and myocardial ischemia group were significantly higher than those in the corresponding control group, and the level of NPY in blood was positively correlated with the degree of left ventricular hypertrophy and myocardial ischemia time. Perindopril in reducing blood NPY concentration and reduce the incidence of arrhythmia, accompanied by myocardial hypertrophy and myocardial ischemia shortened, the correlation analysis also found that the degree of NPY decreased myocardial hypertrophy and shortening of ischemic time is positively correlated. Conclusions The decrease of NPY plays a role in the action of angiotensin Ⅱ inhibitor