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[目的]探讨骨唾液酸蛋白(BSP)与前列腺特异性抗原(PSA)在前列腺癌组织中的表达及意义。[方法]选取不同病理分级的前列腺癌组织(68例)和前列腺增生组织(22例),采用免疫组织化学SP法染色,检测BSP及PSA的表达情况。[结果]BSP在前列腺癌中阳性率为76.47%,显著高于前列腺增生组织(13.64%)(χ2=27.614,P<0.001)。BSP在不同分化程度前列腺癌组织中表达差异无统计学意义(χ2=0.057,P=0.972)。前列腺增生组织、前列腺癌组织的PSA表达率分别为90.91%、69.12%,差异有统计学意义(χ2=4.149,P=0.042)。不同分化程度前列腺癌PSA表达差异有统计学意义(χ2=11.437,P=0.003)。BSP与PSA表达具有显著相关性(rs=0.654,P<0.001)。[结论]BSP在前列腺癌中高表达,与PSA表达相关。BSP可能在前列腺癌的发生、发展中起重要作用,可能成为前列腺癌治疗的新靶点。
[Objective] To investigate the expression and significance of bone sialoprotein (BSP) and prostate-specific antigen (PSA) in prostate cancer. [Method] Prostate cancer tissues (68 cases) and benign prostatic hyperplasia tissues (22 cases) with different pathological grade were selected and the expressions of BSP and PSA were detected by immunohistochemical staining. [Results] The positive rate of BSP in prostate cancer was 76.47%, which was significantly higher than that in benign prostatic hyperplasia (13.64%) (χ2 = 27.614, P <0.001). There was no significant difference in BSP expression in different degree of differentiation of prostate cancer (χ2 = 0.057, P = 0.972). Prostate hyperplasia and prostate cancer PSA expression rates were 90.91%, 69.12%, the difference was statistically significant (χ2 = 4.149, P = 0.042). There was significant difference in the PSA expression between different degrees of differentiation of prostate cancer (χ2 = 11.437, P = 0.003). There was a significant correlation between BSP and PSA expression (rs = 0.654, P <0.001). [Conclusion] BSP is highly expressed in prostate cancer and related to PSA expression. BSP may play an important role in the occurrence and development of prostate cancer and may become a new target for the treatment of prostate cancer.