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用PCR和ELISA技术对195例宫颈癌和75例宫颈良性疾病患者组织标本进行病毒病原体和血清SIL2R、TNF的测定。结果宫颈癌患者组织中HPV16、18、35型检出率为31.79%(62/195);HSVⅡ为30.77%(60/195);HCMV为3.08%(6/195),均高于良性疾病患者的20%、4.0%、6.6%和0,经χ2检验差异显著,均P<0.01。而HPV6.11型、EBV、Uu及CT的检出率在良恶性两组之间比较,差异无显著性,均P>0.05。宫颈癌患者血清SIL2R和TNF水平明显高于良性疾病组,且宫颈癌病毒感染阳性者血清SIL-2R和TNF水平明显高于阴性者,经统计学处理差异显著,均P<0.01。结论HPV16、18、35型、HSVⅡ和HCMV合并感染及血清中TNF和SILIR水平明显升高,可能是山西地区宫颈癌高发的一个重要因素。
The viral pathogens and serum SIL2R and TNF in 195 cases of cervical cancer and 75 cases of cervical benign disease were detected by PCR and ELISA. Results The positive rate of HPV16, HPV18, HPV18 in patients with cervical cancer was 31.79% (62/195), HSVⅡwas 30.77% (60/195), and HCMV was 3.08% (6/195) 20%, 4.0%, 6.6% and 0, respectively. There was significant difference by χ2 test, all P <0.01. The detection rate of HPV6.11, EBV, Uu and CT in the benign and malignant groups was no significant difference (P> 0.05). Serum levels of SIL2R and TNF in patients with cervical cancer were significantly higher than those in patients with benign disease. The levels of serum SIL-2R and TNF in patients with positive cervical cancer were significantly higher than those in patients with negative cervical cancer. The differences were statistically significant (P <0.01). Conclusion HPV16,18,35, HSVⅡ and HCMV combined infection and serum TNF and SILIR levels were significantly increased, which may be an important factor for the high incidence of cervical cancer in Shanxi Province.