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目的:观察急性氟乙酰胺中毒的临床特点,总绪抢救治疗的经验。方法:回顾分析28例急性氟乙酰胺中毒患者的临床特点及治疗和转归。结果:患者均有呕吐、抽搐、ALT和AST升高,7例(25%)出现黄疸,21例(75%)昏迷,11例(39%)心电图提示心肌损害,8例(29%)继发急性肾衰竭,3例合并多脏器衰竭。经排毒、吸氧、给予解毒药乙酰胺、血液净化、抗惊厥及其它对症治疗,22例(79%)存活,6例(21%)死亡,其中3例入院24小时内死于呼吸衰竭,3例死于多器官衰竭;23例予乙酰胺治疗患者中19例(83%)存活,21例给予解毒药基础上血液灌流患者19例(90%)存活。结论:急性氟乙酰胺中毒以呕吐、抽搐、昏迷、肝功能及心肌损害为突出表现,乙酰胺及血液净化能有效治疗急性氟乙酰胺中毒。
Objective: To observe the clinical features of acute fluoroacetamide poisoning, the general treatment of the experience of emergency treatment. Methods: A retrospective analysis of 28 patients with acute fluoroacetamide poisoning clinical features and treatment and prognosis. Results: All patients had vomiting, convulsions, elevated ALT and AST, jaundice in 7 patients (25%), coma in 21 patients (75%), myocardial damage in 11 patients (39%) and damage in 8 patients Acute renal failure, 3 cases of multiple organ failure. Twenty-two patients (79%) survived detoxification, oxygen inhalation, acetamide detoxification, blood purification, anticonvulsant and other symptomatic treatments. Six patients died of respiratory failure within 24 hours (21%), Three died of multiple organ failure; 19 (83%) survived in 23 patients treated with acetamide and 21 (90%) survived in hemoperfusion on 21 patients given antidote. Conclusion: Acute fluoroacetamide poisoning is vomiting, convulsions, coma, liver function and myocardial damage as the outstanding performance, acetamide and blood purification can effectively treat acute fluoroacetamide poisoning.