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目的探讨分析老年脑出血继发多器官功能障碍综合征(MODS)临床特点分析及相关因素。方法 120例老年脑出血昏迷患者,随机分为MODS组(67例)和非MODS组(53例),利用葡萄糖氧化酶测血糖含量,化学发光法检测血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)活性。结果 MODS组的血清白细胞介素明显高于非MODS组;血糖水平、急性生理和慢性健康状况明显高于非MODS组,差异具有统计学意义(P<0.01);MODS组的格拉斯昏迷评分明显低于非MODS组,差异具有统计学意义(P<0.01)。结论老年脑出血昏迷患者血清白细胞介素明显升高、24 h内高血糖、急性生理与慢性健康评分(APACHE-2评分)高为导致MODS出现的相关因素,这几个指标对老年脑出血继发多器官功能障碍综合征的预测有重要意义。
Objective To analyze the clinical features and related factors of multiple organ dysfunction syndrome (MODS) after cerebral hemorrhage in senile patients. Methods One hundred and twenty patients with cerebral hemorrhage coma were randomly divided into MODS group (n = 53) and MODS group (n = 53). Glucose oxidase was used to measure the blood sugar level. Serum interleukin-1 (IL- , Interleukin-6 (IL-6), interleukin-10 (IL-10) activity. Results The levels of serum interleukin in MODS group were significantly higher than those in non-MODS group. The blood glucose level, acute physiology and chronic health status were significantly higher than those in non-MODS group (P <0.01). The Grascon coma score in MODS group was significantly Lower than non-MODS group, the difference was statistically significant (P <0.01). Conclusions Serum interleukin levels in patients with cerebral hemorrhagic coma are significantly higher than those in patients with senile intracerebral hemorrhage. The high blood glucose, acute physiology and chronic health score (APACHE-2) score within 24 h are the related factors leading to the occurrence of MODS. Multiple organ dysfunction syndrome prediction is of great significance.