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目的 了解山莨菪碱 (6 5 4- 2 )、开搏通、立其丁、多巴胺、心痛定等对肾综合征出血热 (HFRS)患者肾功能的影响 ,为临床选择改善肾功能的药物提供依据。方法 共选择 474例 HFRS患者 ,入院后随机分为 6 5 4- 2组、开搏通组、立其丁组、多巴胺组、心痛定组和对照组 ,每组各 79例。结果 前五组在尿蛋白消失时间、 BU N、β2 -微球蛋白复常时间、少尿期发生率、少尿期和多尿期持续时间等方面均优于对照组 ,尤以开搏通组和立其丁组最为明显 (P <0 .0 5、 0 .0 1或0 .0 0 1)。结论 6 5 4- 2、开搏通、立其丁、多巴胺和心痛定能促进 HFRS患者的肾功能恢复 ,而以开搏通和立其丁为优。提示HFRS患者可常规应用 5组所用药物 ,对于重症患者 ,可联合应用 2～ 3种上述药物。
Objective To investigate the effect of anisodamine (6 5 4- 2), capecitabine, rosiglitazone, dopamine and nifedipine on renal function in patients with hemorrhagic fever with renal syndrome (HFRS) in accordance with. Methods A total of 474 patients with HFRS were selected and randomly divided into 655-2 groups, CAP group, Lidacheng group, Dopamine group, Xintongding group and control group with 79 cases in each group. The results of the first five groups were better than the control group in urinary protein disappearance time, BU N, β2 - microglobulin recovery time, the incidence of oliguria, oliguric period and duration of polyuria, The most significant difference was observed between the two groups (P <0.05, 0.01, or 0.0001). CONCLUSIONS: Caifei, Lidoketan, dopamine and nifedipine can promote the recovery of renal function in patients with HFRS, while Camptothecin and Ligusticin are superior. Tip HFRS patients can be routinely used five groups of drugs used, for critically ill patients, can be combined with 2 to 3 kinds of the above drugs.