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目的:研究鸡肉参的抗疲劳作用机制。方法:采用对照组及鸡肉参乙醇提取物低、中、高(1.6,3.2,6.4 g.kg-1.d-1)3个剂量组对小鼠ig 24 d后进行游泳实验,并对血乳酸(LD)、乳酸脱氢酶(LDH)、血清尿素氮(BUN)、肝糖原、肌糖原等进行了测试。结果:其中NS组的肝糖原含量(23.26±15.40)mg.g-1,肌糖原含量(0.65±0.32)mg.g-1,LDH(8 652±2 924)U.L-1,BUN(6.72±1.19)mmol.L-1,LD(9.66±3.78)mmol.L-1。与NS组比较,鸡肉参可提高肝糖原(57.42±21.49)mg.g-1、肌糖原(1.23±0.47)mg.g-1的含量(P<0.01,P<0.05),提高LDH(11 792±2 455)U.L-1的活力(P<0.01),同时降低BUN(4.02±1.19)mmol.L-1和LD(11.84±6.45)mmol.L-1的水平(P<0.01)。结论:鸡肉参具明显的抗疲劳作用,其抗疲劳作用机制主要是通过影响LD,LDH,BUN,肝糖原,肌糖原。
Objective: To study the anti-fatigue mechanism of chicken ginseng. METHODS: Swim test was performed on the mice 24 hours after the mice were given 3 groups of low, medium and high (1.6, 3.2, 6.4 g.kg-1.d-1) doses of the control group and the ethanol extract of chicken ginseng. Lactic acid (LD), lactate dehydrogenase (LDH), serum urea nitrogen (BUN), hepatic glycogen, muscle glycogen, etc. were tested. Results: The liver glycogen content in the NS group was (23.26±15.40) mg.g-1, the muscle glycogen content was (0.65±0.32) mg.g-1, LDH was (8 652±2 924)UL-1, BUN ( 6.72±1.19 mmol.L-1, LD (9.66±3.78) mmol.L-1. Compared with NS group, chicken ginseng could increase the content of hepatic glycogen (57.42±21.49) mg.g-1, muscle glycogen (1.23±0.47) mg.g-1 (P<0.01, P<0.05), and increase LDH. (11 792±2 455) UL-1 activity (P<0.01) and BUN (4.02±1.19) mmol.L-1 and LD (11.84±6.45) mmol.L-1 levels (P<0.01). . Conclusion: Chicken meat has obvious anti-fatigue effect, and its anti-fatigue mechanism mainly affects LD, LDH, BUN, hepatic glycogen and muscle glycogen.